MATK Antibody | anti-MATK antibody

MATK Antibody

Cat. Num. AAA857987

• Gene Names: MATK; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MATK; MATK Antibody; CHK; Csk-homologous kinase; Csk-type protein tyrosine kinase; CTK; DKFZp434N1212; Hematopoietic consensus tyrosine-lacking kinase; HHYLTK; hydroxyaryl-protein kinase; HYL; HYL tyrosine kinase; HYLTK; leukocyte carboxyl-terminal src kinase related; Lsk; megakaryocyte-associated tyrosine kinase; Megakaryocyte-associated tyrosine-protein kinase; MGC1708; MGC2101; Protein kinase HYL; tyrosine kinase MATK; Tyrosine-protein kinase CTK; tyrosylprotein kinase; anti-MATK antibody

• Reactivity: Human, Mouse, Rat
• Specificity: MATK antibody detects endogenous levels of total MATK protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 508

• Applicable Applications for anti-MATK antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:3000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from Internal of human MATK.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

Product Categories/Family for anti-MATK antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Sakano S., Oncogene 9:1155-1161(1994). Bennett B.D., J. Biol. Chem. 269:1068-1074(1994). Avraham S., J. Biol. Chem. 270:1833-1842(1995).

NCBI and Uniprot Product Information

• NCBI GI #: 21450842
• NCBI GeneID: 4145
• NCBI Accession #: NP_002369.2
• NCBI GenBank Nucleotide #: NM_002378.3
• UniProt Accession #: P42679; Q9NST8; B3KNZ9
• Molecular Weight: 51,899 Da
• NCBI Official Full Name: megakaryocyte-associated tyrosine-protein kinase isoform b
• NCBI Official Synonym Full Names: megakaryocyte-associated tyrosine kinase
• NCBI Official Symbol: MATK
• NCBI Official Synonym Symbols: CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• NCBI Protein Information: megakaryocyte-associated tyrosine-protein kinase
• UniProt Protein Name: Megakaryocyte-associated tyrosine-protein kinase
• Protein Family: Maturase
• UniProt Gene Name: MATK
• UniProt Synonym Gene Names: CTK; HYL; CHK

NCBI Description

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.