GRM2 Antibody | anti-GRM2 antibody

GRM2 Antibody

Cat. Num. AAA8510015

• Gene Names: GRM2; GLUR2; mGlu2; GPRC1B; MGLUR2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GRM2; GRM2 Antibody; Metabotropic glutamate receptor 2; mGluR2; GPRC1B; MGLUR2; anti-GRM2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: GRM2 antibody detects endogenous levels of total GRM2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 872

• Applicable Applications for anti-GRM2 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; IF: 1:100-1:500; ELISA: 1:1000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human GRM2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using GRM2 antibody. Immunofluorescence analysis of LOVO cells, using GRM2 antibody.)

References

Flor P.J., Eur. J. Neurosci. 7:622-629(1995). Yasuyuki F., Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. Bonner T.I., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 66529100
• NCBI GeneID: 2912
• NCBI Accession #: NP_000830.2
• NCBI GenBank Nucleotide #: NM_000839.4
• UniProt Accession #: Q14416; Q14CU5; Q52MC6; Q9H3N6; B0M0K7
• Molecular Weight: 95,568 Da
• NCBI Official Full Name: metabotropic glutamate receptor 2 isoform a
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 2
• NCBI Official Symbol: GRM2
• NCBI Official Synonym Symbols: GLUR2; mGlu2; GPRC1B; MGLUR2
• NCBI Protein Information: metabotropic glutamate receptor 2
• UniProt Protein Name: Metabotropic glutamate receptor 2
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM2
• UniProt Synonym Gene Names: GPRC1B; MGLUR2; mGluR2

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

Uniprot Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.