Human, Mouse LKB1 ELISA Kit | LKB1 elisa kit
Phospho-LKB1 (Ser428) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.
Protein type: Autophagy; CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; LKB subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; cytosol; extracellular exosome; membrane; mitochondrion; nucleoplasm; nucleus; TCR signalosome
Molecular Function: ATP binding; LRR domain binding; magnesium ion binding; p53 binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; anoikis; autophagy; axonogenesis; cell cycle arrest; cell differentiation; cellular response to DNA damage stimulus; cellular response to UV-B; establishment of cell polarity; glucose homeostasis; Golgi localization; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of lipid biosynthetic process; negative regulation of TORC1 signaling; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of autophagy; positive regulation of axonogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein localization to nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of transforming growth factor beta receptor signaling pathway; positive thymic T cell selection; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell growth; regulation of dendrite morphogenesis; regulation of protein kinase B signaling; regulation of Wnt receptor signaling pathway; response to ionizing radiation; spermatogenesis; T cell receptor signaling pathway; TCR signalosome assembly; tissue homeostasis; vasculature development; Wnt receptor signaling pathway through beta-catenin
Disease: Pancreatic Cancer; Peutz-jeghers Syndrome; Testicular Germ Cell Tumor
Research Articles on LKB1
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Product Notes
The Human, Mouse LKB1 stk11 (Catalog #AAA9501194) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501194 ELISA Kit recognizes Human, Mouse LKB1. It is sometimes possible for the material contained within the vial of "LKB1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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