Testing Data
(The TFact HOXA11/D11 DNA-Binding ELISA detects active HOXA11/D11 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract.)
Human, Mouse HOXA11/D11 ELISA Kit | HOXA11/D11 elisa kit
HOXA11/D11 TFact DNA-Binding ELISA Kit
Testing Data
(The TFact HOXA11/D11 DNA-Binding ELISA detects active HOXA11/D11 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract.)
Testing Data
(The TFact HOXA11/D11 DNA-Binding ELISA detects active HOXA11/D11 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract.)
NCBI and Uniprot Product Information
NCBI Description
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
Uniprot Description
HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: nucleoplasm; protein complex; transcription factor complex
Molecular Function: sequence-specific DNA binding
Biological Process: anatomical structure morphogenesis; anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; developmental growth; dorsal/ventral pattern formation; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic limb morphogenesis; induction of an organ; male gonad development; mesodermal cell fate specification; metanephros development; multicellular organism development; positive regulation of chondrocyte differentiation; positive regulation of transcription, DNA-templated; proximal/distal pattern formation; single fertilization; skeletal system development; spermatogenesis; transcription, DNA-dependent; uterus development
Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia
Research Articles on HOXA11/D11
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Product Notes
The Human, Mouse HOXA11/D11 hoxa11 (Catalog #AAA9502193) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502193 ELISA Kit recognizes Human, Mouse HOXA11/D11. It is sometimes possible for the material contained within the vial of "HOXA11/D11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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