Human, Mouse FOXO4 ELISA Kit | FOXO4 elisa kit
Phospho-FOXO4 (Thr451) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Description
FOXO4: a transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. IR-induced cellular senescence induces progressive increases in FOXO4, but has little effect on FOXO1 and FOXO3 expression. Two splice-variant isoforms have been described.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; DNA binding transcription factor activity; enzyme binding; identical protein binding; promoter-specific chromatin binding; protein binding; sequence-specific DNA binding; transcription factor binding
Biological Process: aging; cell cycle arrest; insulin receptor signaling pathway; mitotic cell cycle G2/M transition DNA damage checkpoint; muscle organ development; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of G0 to G1 transition; negative regulation of smooth muscle cell differentiation; positive regulation of cell cycle arrest; positive regulation of smooth muscle cell migration; positive regulation of transcription from RNA polymerase II promoter; protein deubiquitination; protein kinase B signaling; regulation of transcription, DNA-templated; response to nutrient levels; stem cell differentiation; transcription from RNA polymerase II promoter
Research Articles on FOXO4
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Product Notes
The Human, Mouse FOXO4 foxo4 (Catalog #AAA9501361) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501361 ELISA Kit recognizes Human, Mouse FOXO4. It is sometimes possible for the material contained within the vial of "FOXO4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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