Human, Mouse FLT3 ELISA Kit | FLT3 elisa kit
Phospho-FLT3 (Tyr599) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Uniprot Description
FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 13q12.2
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; integral component of plasma membrane; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; glucocorticoid receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein complex binding; protein homodimerization activity; protein self-association; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity
Biological Process: B cell differentiation; cellular response to cytokine stimulus; cellular response to glucocorticoid stimulus; cytokine-mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; organ regeneration; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein autophosphorylation; regulation of apoptosis; response to organonitrogen compound; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor signaling pathway
Disease: Leukemia, Acute Lymphoblastic
Research Articles on FLT3
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Product Notes
The Human, Mouse FLT3 flt3 (Catalog #AAA9501106) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501106 ELISA Kit recognizes Human, Mouse FLT3. It is sometimes possible for the material contained within the vial of "FLT3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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