Human, Mouse DNA-PK ELISA Kit | DNA-PK elisa kit
DNA-PK Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
Uniprot Description
DNAPK: an atypical protein kinase of the PIKK family. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. and modulation of transcription. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Defects cause severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections. Required for repair of radiation-induced dsDNA breaks. Loss of function in mice or horses leads to the SCID (severe combined immune deficiency) phenotype due to failure of immunoglobulin rearrangement. Target of mutation in mismatch repair-deficient colorectal cancer. Inhibitor: KU-7059. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: ATYPICAL group; DNA repair, damage; DNAPK subfamily; EC 2.7.11.1; Kinase, protein; Nucleolus; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 8q11.21
Cellular Component: cytosol; DNA-dependent protein kinase-DNA ligase 4 complex; extracellular matrix; membrane; nonhomologous end joining complex; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; protein complex; transcription factor complex
Molecular Function: ATP binding; DNA-dependent protein kinase activity; double-stranded DNA binding; enzyme binding; protein binding; protein domain specific binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding; transcription factor binding
Biological Process: activation of innate immune response; B cell lineage commitment; brain development; cell proliferation; cellular protein modification process; cellular response to insulin stimulus; DNA damage response, signal transduction resulting in induction of apoptosis; double-strand break repair; double-strand break repair via nonhomologous end joining; germ cell programmed cell death; heart development; immunoglobulin V(D)J recombination; innate immune response; negative regulation of apoptosis; negative regulation of cellular senescence; negative regulation of immunoglobulin production; negative regulation of protein phosphorylation; negative regulation of response to gamma radiation; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of developmental growth; positive regulation of fibroblast proliferation; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; pro-B cell differentiation; protein amino acid phosphorylation; protein destabilization; protein ubiquitination; regulation of circadian rhythm; regulation of smooth muscle cell proliferation; response to activity; response to gamma radiation; rhythmic process; signal transduction involved in mitotic G1 DNA damage checkpoint; somitogenesis; spleen development; T cell differentiation in thymus; T cell lineage commitment; T cell receptor V(D)J recombination; telomere capping; thymus development
Disease: Immunodeficiency 26 With Or Without Neurologic Abnormalities
Research Articles on DNA-PK
Similar Products
Product Notes
The Human, Mouse DNA-PK prkdc (Catalog #AAA9500181) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500181 ELISA Kit recognizes Human, Mouse DNA-PK. It is sometimes possible for the material contained within the vial of "DNA-PK, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
