COL4A3BP blocking peptide

COL4A3BP Immunizing Peptide

Cat. Num. AAA428224

• Gene Names: COL4A3BP; CERT; GPBP; CERTL; MRD34; STARD11
• Reactivity: Human, Mouse
• Synonyms: COL4A3BP; COL4A3BP Immunizing Peptide; collagen; type IV; alpha 3 (Goodpasture antigen) binding protein; CERT; CERTL; FLJ20597; GPBP; STARD11; Goodpasture antigen-binding protein; START domain containing 11; alpha 3 type IV collagen binding protein; ceramide transporter; COL4A3BP (aa662-672); COL4A3BP blocking peptide

• Reactivity: Human, Mouse
• Form/Format: 100ug of dried peptide
• Sequence: DHDSAPLNNRC
• Sequence Length: 624

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 5031717
• NCBI GeneID: 10087
• NCBI Accession #: NP_005704.1; NP_112729.1
• NCBI GenBank Nucleotide #: NM_005713.2
• Molecular Weight: 83,708 Da
• NCBI Official Full Name: collagen type IV alpha-3-binding protein isoform 1
• NCBI Official Synonym Full Names: collagen type IV alpha 3 binding protein
• NCBI Official Symbol: COL4A3BP
• NCBI Official Synonym Symbols: CERT; GPBP; CERTL; MRD34; STARD11
• NCBI Protein Information: collagen type IV alpha-3-binding protein
• UniProt Protein Name: Collagen type IV alpha-3-binding protein
• Protein Family: Collagen type IV alpha-3-binding protein
• UniProt Gene Name: COL4A3BP
• UniProt Synonym Gene Names: CERT; STARD11; hCERT; GPBP; StARD11
• UniProt Entry Name: C43BP_HUMAN

NCBI Description

This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

COL4A3BP: a protein with a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. Implicated in human autoimmune diseases via its association with the Goodpasture antigen. Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. GPBP has been reported to have Ser/Thr protein kinase activity towards the Goodpasture (GP) antigen, but lacks a conventional serine/threonine kinase domain. Two human isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Lipid-binding; EC 2.7.11.9; ATYPICAL group; COL4A3BP family

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: cytosol; endoplasmic reticulum membrane; Golgi apparatus; mitochondrion; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: protein binding; protein kinase activity

Biological Process: cell morphogenesis; cell proliferation; ceramide metabolic process; endoplasmic reticulum organization and biogenesis; heart morphogenesis; immune response; in utero embryonic development; lipid homeostasis; muscle contraction; protein amino acid phosphorylation; signal transduction; sphingolipid biosynthetic process

Disease: Mental Retardation, Autosomal Dominant 34