anti-Human, Mouse GPR143 Antibody | anti-GPR143 antibody

GPR143 Antibody

Cat. Num. AAA852832

• Gene Names: GPR143; OA1; NYS6
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GPR143; GPR143 Antibody; G-protein coupled receptor 143; Ocular albinism type 1 protein; OA1; anti-GPR143 antibody

• Reactivity: Human, Mouse
• Specificity: GPR143 antibody detects endogenous levels of total GPR143 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 404

• Applicable Applications for anti-GPR143 antibody: Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IF: 1:100-1:500; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human GPR143.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunofluorescence (IF)

(Peptide-+ Immunofluorescence analysis of LOVO cells, using GPR143 antibody.)

Product Categories/Family for anti-GPR143 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Bassi M.T., Nat. Genet. 10:13-19(1995). Ross M.T., Nature 434:325-337(2005). Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 270265839
• NCBI GeneID: 4935
• NCBI Accession #: NP_000264.2
• NCBI GenBank Nucleotide #: NM_000273.2
• UniProt Accession #: P51810; Q6NTI7
• Molecular Weight: 43,878 Da
• NCBI Official Full Name: G-protein coupled receptor 143
• NCBI Official Synonym Full Names: G protein-coupled receptor 143
• NCBI Official Symbol: GPR143
• NCBI Official Synonym Symbols: OA1; NYS6
• NCBI Protein Information: G-protein coupled receptor 143
• UniProt Protein Name: G-protein coupled receptor 143
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR143
• UniProt Synonym Gene Names: OA1

NCBI Description

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

Uniprot Description

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.