Testing Data
(Image: Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.)
anti-Human, Mouse Doublecortin Antibody | anti-DCX antibody
Doublecortin, Affinity Purified Antibody
Gene Names
DCX; DC; DBCN; LISX; SCLH; XLIS
Reactivity
Human, Mouse
Applications
Immunocytochemistry, Immunohistochemistry
Synonyms
Doublecortin; Affinity Purified Antibody; anti-DCX antibody
Reactivity
Human, Mouse
Form/Format
Affinity Purified - Liquid
Sequence Length
360
Applicable Applications for anti-DCX antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC)
Type Info
Chicken IgY
Immunogen
Peptide common to mouse (AAT58219.1) and human (CAA06617.1) Doublecortin
Preparation and Storage
Store at 4-8 degrees
Testing Data
(Image: Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.)
Testing Data
(Image: Cochlear neurons in the cochlear ganglion of an adult mouse brain stained green with doublecortin. Neurofilament immunoreactivity stained red using a rabbit antibody.)
Related Product Information for anti-DCX antibody
Doublecortin (also known as doublecortex, lissencephalin) a microtubule-associated phosphoprotein coded by the gene DCX. Doublecortin binds to microtubules during neuronal migration promoting stability. Doublecortin immunostaining can be used as a marker of new neurons in the adult dentate gyrus and could be used to analyze changes in dentate neurogenesis in hippocampal tissue to study ageing or neurodegenerative diseases.
Mutations to the gene DCX has been shown to lead to isolated lissencephaly sequence (ILS). Individuals with ILS have abnormal brain development that results in lissenecephaly (smooth appearance) instead of the brain's normal gyri and sulci. Mutations to DCX can also lead to subcortical band heterotopia; which is the migration of neurons to incorrect locations in the brain.
Mutations to the gene DCX has been shown to lead to isolated lissencephaly sequence (ILS). Individuals with ILS have abnormal brain development that results in lissenecephaly (smooth appearance) instead of the brain's normal gyri and sulci. Mutations to DCX can also lead to subcortical band heterotopia; which is the migration of neurons to incorrect locations in the brain.
Product Categories/Family for anti-DCX antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
40,044 Da
NCBI Official Full Name
doublecortin
NCBI Official Synonym Full Names
doublecortin
NCBI Official Symbol
DCX
NCBI Official Synonym Symbols
DC; DBCN; LISX; SCLH; XLIS
NCBI Protein Information
neuronal migration protein doublecortin
UniProt Protein Name
Neuronal migration protein doublecortin
Protein Family
UniProt Gene Name
DCX
UniProt Synonym Gene Names
DBCN; LISX; Lis-X
UniProt Entry Name
DCX_HUMAN
Uniprot Description
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Similar Products
Product Notes
The DCX dcx (Catalog #AAA555568) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Doublecortin, Affinity Purified Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Doublecortin can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the DCX dcx for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Doublecortin, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
