Carcinoembryonic Antigen (CEA) Antigen Grade Native Protein | CEACAM6 native protein
CEA Antigen Grade
Gene Names
CEACAM6; NCA; CEAL; CD66c; CEACAM6
Applications
ELISA
Purity
Immunoaffinity purification. SDS-PAGE denaturing: multiple protein bands 150-210kDa
Synonyms
Carcinoembryonic Antigen (CEA) Antigen Grade; CEA Antigen Grade; CEACAM6 native protein
Host
Human Metastatic Liver
Specificity
Carcinoembryonic Antigen (CEA) Antigen Grade
Purity/Purification
Immunoaffinity purification. SDS-PAGE denaturing: multiple protein bands 150-210kDa
Form/Format
Affinity Purified, Liquid
Concentration
4.50 mg/ml (varies by lot)
Sequence Length
141
Applicable Applications for CEACAM6 native protein
EIA/ELISA
Application Notes
Suitable as an immunogen for antisera production, tracer for iodination and stadard for immunoassay.
Inactivation
Not applicable
Buffer
0.1M PBS, pH 7.4 containing 2% Methyl-mannoside
Preservative
0.2% Sodium azide
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains. A blood sample from the tissue donor tested negative for HIV 1, HIV 2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Preparation and Storage
Upon receipt, store at -20 degree C. Avoid multiple freeze/thaw cycles.
Product Categories/Family for CEACAM6 native protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
15,545 Da
NCBI Official Full Name
carcinoembryonic antigen
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
NCBI Official Symbol
CEACAM6
NCBI Official Synonym Symbols
NCA; CEAL; CD66c; CEACAM6
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
UniProt Protein Name
Carcinoembryonic antigen
Protein Family
UniProt Gene Name
CEA
UniProt Entry Name
Q13985_HUMAN
NCBI Description
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Uniprot Description
CEACAM6: Belongs to the immunoglobulin superfamily. CEA family
Protein type: Membrane protein, GPI anchor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell-cell signaling; signal transduction; blood coagulation; leukocyte migration
Research Articles on CEACAM6
1. CEACAM6-associated signaling pathways could be potential targets for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics
2. Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein
3. Data show that desensitization of neutrophils to any two CEACAMs, 1, 3, 6, or 8, results in selective desensitization to those two CEACAMs, while the cells remain responsive to the other two neutrophil CEACAMs.
4. CEACAM6 is overexpressed in borderline and invasive mucinous ovarian neoplasms.
5. findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.
6. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes.
7. data support an important role for CEACAM6 in endocrine resistance in breast cancer, which can serve as a powerful predictor of future recurrence
8. Observational study of gene-disease association. (HuGE Navigator)
9. The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions.
10. CEACAM6 is a biological tumor marker for epithelial ovarian cancers.
11. the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions
12. For all tumors, the amount of CEACAM6 expressed was greater than that of CEACAM5, and reflected tumor histotype.
13. CEACAM6 subdomains involved in intercellular adhesion activity and subdomains involved in inhibition of cell differentation are identified and their respective activities are independently blocked.
14. overexpression among human malignancies, immunological targeting of this tumor antigen may have therapeutic applicability
15. Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
16. Data show that variants of Neisseria gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 1 and 6 failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM.
17. CEACAM6 gene silencing reversed the acquired anoikis resistance of tumor cell lines and inhibited in vivo metastatic ability
18. CEACAM6 is an important determinant of pancreatic adenocarcinoma malignant cellular behavior
19. CD66c is regulated in a manner distinct from other myeloid antigens in childhood lymphoblastic leukemia
20. Overexpression of CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
2. Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein
3. Data show that desensitization of neutrophils to any two CEACAMs, 1, 3, 6, or 8, results in selective desensitization to those two CEACAMs, while the cells remain responsive to the other two neutrophil CEACAMs.
4. CEACAM6 is overexpressed in borderline and invasive mucinous ovarian neoplasms.
5. findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.
6. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes.
7. data support an important role for CEACAM6 in endocrine resistance in breast cancer, which can serve as a powerful predictor of future recurrence
8. Observational study of gene-disease association. (HuGE Navigator)
9. The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions.
10. CEACAM6 is a biological tumor marker for epithelial ovarian cancers.
11. the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions
12. For all tumors, the amount of CEACAM6 expressed was greater than that of CEACAM5, and reflected tumor histotype.
13. CEACAM6 subdomains involved in intercellular adhesion activity and subdomains involved in inhibition of cell differentation are identified and their respective activities are independently blocked.
14. overexpression among human malignancies, immunological targeting of this tumor antigen may have therapeutic applicability
15. Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
16. Data show that variants of Neisseria gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 1 and 6 failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM.
17. CEACAM6 gene silencing reversed the acquired anoikis resistance of tumor cell lines and inhibited in vivo metastatic ability
18. CEACAM6 is an important determinant of pancreatic adenocarcinoma malignant cellular behavior
19. CD66c is regulated in a manner distinct from other myeloid antigens in childhood lymphoblastic leukemia
20. Overexpression of CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
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Product Notes
The CEACAM6 cea (Catalog #AAA318318) is a Native Protein produced from Human Metastatic Liver and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Carcinoembryonic Antigen (CEA) Antigen Grade can be used in a range of immunoassay formats including, but not limited to, EIA/ELISA. Suitable as an immunogen for antisera production, tracer for iodination and stadard for immunoassay. Researchers should empirically determine the suitability of the CEACAM6 cea for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Carcinoembryonic Antigen (CEA) Antigen Grade, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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