CD40:Fc Active Protein | C1qb active protein

CD40:Fc, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor)

Cat. Num. AAA636995

• Purity: Highly Purified; >95% (SDS-PAGE)
• Synonyms: CD40:Fc; Recombinant; Human (Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5; CD40L Receptor); C1qb active protein

• Host: Human, HEK 293 cells
• Specificity: Binds human and mouse CD40L.
• Purity/Purification: Highly Purified; >95% (SDS-PAGE)
• Form/Format: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
• Sequence: The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193).

• Biological Activity: Blocks the binding of CD40L to CD40.
• Preparation and Storage: Short-term Storage: +4 degree C; Long-term Storage: -20 degree C; Stable for at least 6 months after receipt when stored at -20 degree C.

Related Product Information for C1qb active protein

CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

Product Categories/Family for C1qb active protein

Molecular Biology; MB-CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 408359989
• NCBI GeneID: 12260
• UniProt Accession #: P14106; Q3U793
• Molecular Weight: ~54kD (SDS-PAGE)
• NCBI Official Full Name: Complement C1q subcomponent subunit B
• NCBI Official Synonym Full Names: complement component 1, q subcomponent, beta polypeptide
• NCBI Official Symbol: C1qb
• NCBI Protein Information: complement C1q subcomponent subunit B
• UniProt Protein Name: Complement C1q subcomponent subunit B
• Protein Family: Complement C1q subcomponent
• UniProt Gene Name: C1qb
• UniProt Entry Name: C1QB_MOUSE

Uniprot Description

C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein homodimerization activity

Biological Process: immune system process; innate immune response; inner ear development; complement activation, classical pathway