Myoglobin, Cardiac Protein | MB protein

Myoglobin, Cardiac (MB)

Cat. Num. AAA634275

• Gene Names: MB; PVALB
• Applications: ELISA
• Purity: Highly Purified; Purified by ion-exchange and gel-filtration chromatography (~98%, SDS-PAGE).
• Synonyms: Myoglobin; Cardiac; Cardiac (MB); MB protein

• Host: Human Heart
• Purity/Purification: Highly Purified; Purified by ion-exchange and gel-filtration chromatography (~98%, SDS-PAGE).
• Form/Format: Supplied as a lyophilized powder from 20mM Tris HCl, pH 8.5. Reconstitute with sterile dH2O.

• Applicable Applications for MB protein: ELISA (EL/EIA)
• Application Notes: Suitable for use as a reference or standard in immunoassay, immunogen for antisera production, labeling.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for MB protein

Myoglobin is a cytoplasmic, single chain polypeptide of 153 amino acids. It contains a single heme group. Myoglobin is found in skeletal and carciac muscle. It is not in smooth muscle. it functions as an oxygen transporting pigment. Upon damage to the muscle cell due to infarction of a coronary artery, neurological trauma, infection of tumor processes, myoglobin escapes to the environment and can be found in plasma using sensitive assays.

Product Categories/Family for MB protein

Molecular Biology; MB-Serum Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 44955888
• NCBI GeneID: 4151
• NCBI Accession #: NP_976312.1
• NCBI GenBank Nucleotide #: NM_203378.1
• UniProt Accession #: P02144; Q52H51; Q5THY7
• Molecular Weight: 17,184 Da
• NCBI Official Full Name: myoglobin
• NCBI Official Synonym Full Names: myoglobin
• NCBI Official Symbol: MB
• NCBI Official Synonym Symbols: PVALB
• NCBI Protein Information: myoglobin
• UniProt Protein Name: Myoglobin
• Protein Family: Myoglobin
• UniProt Gene Name: MB
• UniProt Entry Name: MYG_HUMAN

NCBI Description

This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

MB: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 22q13.1

Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: slow-twitch skeletal muscle fiber contraction; response to hydrogen peroxide; oxygen transport; heart development; response to hypoxia; response to hormone stimulus; brown fat cell differentiation; enucleate erythrocyte differentiation