IL-17F elispot set

Human IL-17F ELISpot Set

Cat. Num. AAA335596

• Gene Names: IL17F; ML1; ML-1; CANDF6; IL-17F
• Reactivity: Human. No cross reactivity with other human cytokines.
• Synonyms: IL-17F; Human IL-17F ELISpot Set; IL-17F (without plate); IL-17F elispot set

• Reactivity: Human. No cross reactivity with other human cytokines.
• Specificity: Recognizes natural human IL-17F
• Sequence Length: 163

• Samples: Dilute CD4+ cells in culture medium and stimulator of interest (i.e. Sample, Vaccine, Peptide pool or infected cells) to give an appropriate cell number per 100ml. Optimal assay performances are observed between 1x105 and 2.5x105 cells per 100ml. Stimulators and incubation times can be varied depending on the frequency of cytokine producing cells and therefore should be optimised by the testing laboratory.

Related Product Information for IL-17F elispot set

MyBioSource ELISpot Sets include capture and detection antibodies, Streptavidin - Alkaline Phosphatase conjugated, BSA, BCIP/NTB, blocking reagent.

Product Categories/Family for IL-17F elispot set

Human ELISpot Set

NCBI and Uniprot Product Information

• NCBI GI #: 16418375
• NCBI GeneID: 112744
• NCBI Accession #: NP_443104.1
• NCBI GenBank Nucleotide #: NM_052872.3
• UniProt Accession #: Q96PD4; Q6NSI0; Q7Z6P4; Q96PI8; Q9NUE6
• Molecular Weight: 18,045 Da
• NCBI Official Full Name: interleukin-17F
• NCBI Official Synonym Full Names: interleukin 17F
• NCBI Official Symbol: IL17F
• NCBI Official Synonym Symbols: ML1; ML-1; CANDF6; IL-17F
• NCBI Protein Information: interleukin-17F
• UniProt Protein Name: Interleukin-17F
• UniProt Gene Name: IL17F
• UniProt Synonym Gene Names: IL-17F
• UniProt Entry Name: IL17F_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Uniprot Description

IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity

Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-2 biosynthetic process; cytokine biosynthetic process; cartilage development; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; lymphotoxin A biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Disease: Candidiasis, Familial, 6