Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Zinc transporter ZIP4 (SLC39A4) Standard Curve.)
Human Zinc Transporter ZIP4 (SLC39A4) ELISA Kit | ZIP4 elisa kit
Human Zinc Transporter ZIP4 (SLC39A4) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Zinc transporter ZIP4 (SLC39A4) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Zinc transporter ZIP4 (SLC39A4) Standard Curve.)
Background: SLC39A4 gene as a candidate intestinal zinc-specific transporter within the susceptibility locus for the zinc-deficiency type of acrodermatitis enteropathica (AEZ) on 8q24.3. The gene is expressed as an mRNA of 2.5 kb in only a few tissues, i.e., kidney, colon, duodenum and jejunum. The duodenum and jejunum are crucial sites of zinc absorption. These transcripts encode proteins of 647 and 622 amino acids sharing the same C-terminal 583 residues. Computational analysis predicted that the larger protein has a cytoplasmic membrane location and a secondary structure characteristic of a ZIP protein, consisting of 8 transmembrane domains organized in 2 blocks of 3 and 5, respectively. These 2 blocks are separated by a variable intracytoplasmic metal-binding site.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Description
SLC39A4: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: recycling endosome membrane; apical plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane
Molecular Function: zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; transmembrane transport
Disease: Acrodermatitis Enteropathica, Zinc-deficiency Type
Research Articles on ZIP4
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Product Notes
The Human ZIP4 slc39a4 (Catalog #AAA9714267) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714267 ELISA Kit recognizes Human ZIP4. It is sometimes possible for the material contained within the vial of "Zinc Transporter ZIP4 (SLC39A4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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