Human Tyrosine Kinase 2 (Tyk2) ELISA Kit | Tyk2 elisa kit

Human Tyrosine Kinase 2 (Tyk2) ELISA Kit

Cat. Num. AAA454381

• Gene Names: TYK2; JTK1; IMD35
• Reactivity: Human
• Synonyms: Tyrosine Kinase 2 (Tyk2); Human Tyrosine Kinase 2 (Tyk2) ELISA Kit; CI-75Kd; NADH-Coenzyme Q Reductase; NADH Dehydrogenase Iron-Sulfur Protein 1; Tyk2 elisa kit

• Reactivity: Human
• Sequence Length: 1187

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.097ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 187608615
• NCBI GeneID: 7297
• NCBI Accession #: NP_003322.3
• NCBI GenBank Nucleotide #: NM_003331.4
• UniProt Accession #: P29597; Q6QB10; Q96CH0
• Molecular Weight: 133,650 Da
• NCBI Official Full Name: non-receptor tyrosine-protein kinase TYK2
• NCBI Official Synonym Full Names: tyrosine kinase 2
• NCBI Official Symbol: TYK2
• NCBI Official Synonym Symbols: JTK1; IMD35
• NCBI Protein Information: non-receptor tyrosine-protein kinase TYK2
• UniProt Protein Name: Non-receptor tyrosine-protein kinase TYK2
• Protein Family: Non-receptor tyrosine-protein kinase
• UniProt Gene Name: TYK2

NCBI Description

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Uniprot Description

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.