Human Transcription factor MafK (MAFK) ELISA Kit | MAFK elisa kit
Human Transcription factor MafK (MAFK) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
Uniprot Description
MAFK: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Belongs to the bZIP family. Maf subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: nucleoplasm
Molecular Function: transcription factor activity
Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; blood coagulation
Research Articles on MAFK
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Product Notes
The Human MAFK mafk (Catalog #AAA7218444) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7218444 ELISA Kit recognizes Human MAFK. It is sometimes possible for the material contained within the vial of "Transcription factor MafK (MAFK), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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