Human Tie-1 ELISA Kit | Tie-1 elisa kit

Tie-1 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502082

• Gene Names: TIE1; TIE; JTK14
• Reactivity: Human
• Synonyms: Tie-1; Tie-1 (Human) OmniKine ELISA Kit; Tyrosine-protein kinase receptor Tie-1; TIE; Tie-1 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human Tie-1 ELISA is capable of recognizing both recombinant and naturally produced Human Tie-1 proteins. The antigens listed below were tested at 100 ng/ml and did not exhibit significant cross reactivity or interference.; Human: PDGF sR, PDGF R, Tie-2, VEGF R2, VEGF R3; Murine: Tie-1
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 1138

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 157-10000 pg/ml
• Sensitivity: 157-10000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human Tie-1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Tie-1 proteins within the range of 157-10000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4885631
• NCBI GeneID: 7075
• NCBI Accession #: NP_005415.1
• NCBI GenBank Nucleotide #: NM_005424.4
• UniProt Accession #: P35590; B5A949; B5A950
• Molecular Weight: 34,138 Da
• NCBI Official Full Name: tyrosine-protein kinase receptor Tie-1 isoform 1
• NCBI Official Synonym Full Names: tyrosine kinase with immunoglobulin like and EGF like domains 1
• NCBI Official Symbol: TIE1
• NCBI Official Synonym Symbols: TIE; JTK14
• NCBI Protein Information: tyrosine-protein kinase receptor Tie-1
• UniProt Protein Name: Tyrosine-protein kinase receptor Tie-1
• UniProt Gene Name: TIE1
• UniProt Synonym Gene Names: TIE

NCBI Description

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

TIE1: a transmembrane tyrosine-protein kinase that modulates TEK/TIE2 activity and contribute to the regulation of angiogenesis. An endothelial cell specific ligand-receptor necessary for lymphatic development, angiogenesis, vascular remodelling, permeability and inflammation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: integral component of plasma membrane

Molecular Function: ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: angiogenesis; in utero embryonic development; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; response to retinoic acid; signal transduction; vasculogenesis