Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Sodium/glucose cotransporter 2 (SLC5A2) Standard Curve.)
Human Sodium/Glucose Cotransporter 2 (SLC5A2) ELISA Kit | SLC5A2 elisa kit
Human Sodium/Glucose Cotransporter 2 (SLC5A2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Sodium/glucose cotransporter 2 (SLC5A2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Sodium/glucose cotransporter 2 (SLC5A2) Standard Curve.)
Background: The major reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na(+)/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and has a Na(+)-to-glucose coupling ratio of 1:1.Uptake experiments using cRNA-injected Xenopus oocytes showed specific uptake of glucose and alpha-methyl glucopyranoside at up to three times background. This uptake was saturable, suggesting that the cDNA corresponds to a low-affinity kidney sodium-glucose transporter. It was therefore referred to as sodium-glucose cotransporter 2, or SGLT2. SGLT2 mediates saturable Na(+)-dependent and phlorizin-sensitive transport with K(m) values consistent with low affinity Na(+)/glucose cotransport.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
Uniprot Description
SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: low-affinity glucose:sodium symporter activity
Biological Process: transport; sodium ion transport; carbohydrate metabolic process; glucose transport; transmembrane transport
Disease: Renal Glucosuria
Research Articles on SLC5A2
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Product Notes
The Human SLC5A2 slc5a2 (Catalog #AAA9714262) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714262 ELISA Kit recognizes Human SLC5A2. It is sometimes possible for the material contained within the vial of "Sodium/Glucose Cotransporter 2 (SLC5A2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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