Human SLPI ELISA Kit | SLPI elisa kit

SLPI, Human, ELISA Kit

Cat. Num. AAA584606

• Reactivity: Human
• Synonyms: SLPI; Human; ELISA Kit; SLPI elisa kit

• Reactivity: Human
• Sequence Length: 132

• Application Notes: Application Notes: The human SLPI ELISA has been developed for the quantitative measurement of natural and recombinant human SLPI in cell culture medium, plasma or serum, sputum, urine and many other body fluids. In serum or plasma samples human SLPI can be measured accurately if serum or plasma samples are diluted at least 10 times.
• Samples: Serum, plasma, urine, sputum, BALF and Cell Culture Supernatant samples
• Intended Uses: The human SLPI ELISA kit is to be used for the in vitro quantitative determination of human SLPI in serum, plasma, urine, sputum, BALF and cell culture supernatant samples. This kit is intended for laboratory research use only and is not for use in therapeutic procedures. The analysis should be performed by trained laboratory professionals.
• Preparation and Storage: Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

References

1. Kramps, J et al; ELISA for quantitative measurement of low-molecular-weight bronchial protease inhibitor in human sputum. Am Rev Respir Dis 1984, 129: 959
2. Fahey, J et al; Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in culture. J Infect Dis 2002, 185: 1606
3. Devoogdt, N et al; Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells. PNAS 2003, 100: 5778
4. Higashimoto, Y et al; Adenoviral E1A suppresses secretory leukoprotease inhibitor and elafin secretion in human alveolar epithelial cells and bronchial epithelial cells. Respiration 2005, 72: 629
5. Stock, S et al; Natural antimicrobial production by the amnion. Am J Obstet Gynecol 2007, 196: 255
6. Anderson, R et al; Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome. Eur Respir J 2008, 32: 670
7. L³pez-Bermejo, A et al; The alarm secretory leukocyte protease inhibitor increases with progressive metabolic dysfunction. Clin Chim Acta 2011

NCBI and Uniprot Product Information

• NCBI GI #: 758101
• UniProt Accession #: P03973; P07757; B2R5H8
• Molecular Weight: 14,326 Da
• NCBI Official Full Name: secretory leukocyte protease inhibitor (SLPI)
• UniProt Protein Name: Antileukoproteinase
• Protein Family: Antileukoproteinase
• UniProt Gene Name: SLPI
• UniProt Synonym Gene Names: WAP4; WFDC4; ALP; MPI
• UniProt Entry Name: SLPI_HUMAN

Uniprot Description

SLPI: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: extracellular matrix

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; endopeptidase inhibitor activity

Biological Process: negative regulation of viral genome replication; negative regulation of protein binding