Human Protein Tyrosine Phosphatase 1B (PTP1B) ELISA Kit | PTP1B elisa kit

Human Protein Tyrosine Phosphatase 1B (PTP1B) ELISA Kit

Cat. Num. AAA3800489

• Gene Names: PTPN1; PTP1B
• Reactivity: Human
• Synonyms: Protein Tyrosine Phosphatase 1B (PTP1B); Human Protein Tyrosine Phosphatase 1B (PTP1B) ELISA Kit; PTP1B elisa kit

• Reactivity: Human
• Sequence Length: 10

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 4 pg/ml-64 pg/ml
• Sensitivity: 0.1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PTP1B elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofPTP1Bin the sample, This PTP1BELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusPTP1Bconcentration. The concentration ofPTP1Bin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 13919645
• NCBI GeneID: 5770
• NCBI Official Full Name: protein tyrosine phosphatase 1B, partial
• NCBI Official Synonym Full Names: protein tyrosine phosphatase non-receptor type 1
• NCBI Official Symbol: PTPN1
• NCBI Official Synonym Symbols: PTP1B
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 1

NCBI Description

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]