Human Protein Tob1 ELISA Kit | TOB1 elisa kit
Human Protein Tob1 (TOB1) ELISA Kit
Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate TOB1 in Human serum, plasma. An antibody specific for TOB1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TOB1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TOB1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TOB1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
TOB1: Anti-proliferative protein that interacts with the erbB- 2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. Belongs to the BTG family.
Protein type: Adaptor/scaffold; Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: CCR4-NOT complex; cytoplasm; nucleus
Molecular Function: protein binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; SMAD binding; transcription corepressor activity
Biological Process: BMP signaling pathway; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; negative regulation of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of signal transduction; SMAD protein import into nucleus
Research Articles on TOB1
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Product Notes
The Human TOB1 tob1 (Catalog #AAA282569) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA282569 ELISA Kit recognizes Human TOB1. It is sometimes possible for the material contained within the vial of "Protein Tob1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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