Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) Standard Curve.)
Human Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) ELISA Kit | KCNN2 elisa kit
Human Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) Standard Curve.)
Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.
NCBI and Uniprot Product Information
NCBI Description
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Description
KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q22.3
Cellular Component: smooth endoplasmic reticulum; cell soma; T-tubule; plasma membrane; integral to membrane; dendritic spine; Z disc
Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein homodimerization activity; alpha-actinin binding; small conductance calcium-activated potassium channel activity
Biological Process: synaptic transmission; potassium ion transport
Research Articles on KCNN2
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Product Notes
The Human KCNN2 kcnn2 (Catalog #AAA9716201) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716201 ELISA Kit recognizes Human KCNN2. It is sometimes possible for the material contained within the vial of "Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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