Human Pim-3 Oncogene (PIM3) ELISA Kit | PIM3 elisa kit

Human Pim-3 Oncogene (PIM3) ELISA Kit

Cat. Num. AAA451490

• Gene Names: PIM3; pim-3
• Reactivity: Human
• Synonyms: Pim-3 Oncogene (PIM3); Human Pim-3 Oncogene (PIM3) ELISA Kit; Serine/threonine-protein kinase pim-3; PIM3 elisa kit

• Reactivity: Human
• Sequence Length: 326

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.625-40ng/mL
• Sensitivity: 0.228ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 224591416
• NCBI GeneID: 415116
• NCBI Accession #: NP_001001852.2
• NCBI GenBank Nucleotide #: NM_001001852.3
• UniProt Accession #: Q86V86; Q68BM2; A5D8X8; A8K7J0; B1B0P0
• Molecular Weight: 35,891 Da
• NCBI Official Full Name: serine/threonine-protein kinase pim-3
• NCBI Official Synonym Full Names: Pim-3 proto-oncogene, serine/threonine kinase
• NCBI Official Symbol: PIM3
• NCBI Official Synonym Symbols: pim-3
• NCBI Protein Information: serine/threonine-protein kinase pim-3
• UniProt Protein Name: Serine/threonine-protein kinase pim-3
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PIM3

NCBI Description

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

Uniprot Description

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.