Human Nucleolar Protein 3 (NOL3) ELISA Kit | NOL3 elisa kit

Human Nucleolar Protein 3 (NOL3) ELISA Kit

Cat. Num. AAA9311420

• Gene Names: NOL3; ARC; FCM; MYP; NOP; NOP30
• Reactivity: Human
• Synonyms: Nucleolar Protein 3 (NOL3); Human Nucleolar Protein 3 (NOL3) ELISA Kit; NOL3 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 443929381
• NCBI GeneID: 8996
• NCBI Accession #: NP_001263240.1
• NCBI GenBank Nucleotide #: NM_001276311.1
• UniProt Accession #: O60936; O60937
• Molecular Weight: 24,327 Da
• NCBI Official Full Name: nucleolar protein 3 isoform C
• NCBI Official Synonym Full Names: nucleolar protein 3 (apoptosis repressor with CARD domain)
• NCBI Official Symbol: NOL3
• NCBI Official Synonym Symbols: ARC; FCM; MYP; NOP; NOP30
• NCBI Protein Information: nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein
• UniProt Protein Name: Nucleolar protein 3
• Protein Family: Nucleolar protein
• UniProt Gene Name: NOL3
• UniProt Synonym Gene Names: ARC; NOP; Myp; Nop30
• UniProt Entry Name: NOL3_HUMAN

NCBI Description

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

Function: Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.

Subunit structure: Interacts with TFPT

By similarity. Isoform 1 oligomerizes and binds to SFRS9/SRp30C and also interacts with NPM1. Isoform 2 binds CASP2/caspase-2 and CASP8/caspase-8 and inhibits caspase-8 activity. Ref.1

Subcellular location: Isoform 1: Nucleus › nucleolus. Isoform 2: Cytoplasm.

Tissue specificity: Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.

Sequence similarities: Contains 1 CARD domain.