Human NLRP2/NACHT, LRR And PYD Domains-Containing Protein 2 ELISA Kit | NLRP2 elisa kit

Human NLRP2/NACHT, LRR And PYD Domains-Containing Protein 2 ELISA Kit

Cat. Num. AAA2890233

• Gene Names: NLRP2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• Reactivity: Human
• Synonyms: NLRP2/NACHT; LRR And PYD Domains-Containing Protein 2; Human NLRP2/NACHT; LRR And PYD Domains-Containing Protein 2 ELISA Kit; NACHT; LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; NALP2; NBS1; PAN1; PYPAF2; NLRP2 elisa kit

• Reactivity: Human
• Specificity: Natural and recombinant Human NACHT, LRR and PYD domains-containing protein 2
• Sequence Length: 1062

• Assay Type: Sandwich
• Detection Range: 31.2-2000pg/mL
• Sensitivity: 15.69pg/mL
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 8923473
• NCBI GeneID: 55655
• NCBI Accession #: NP_060322
• NCBI GenBank Nucleotide #: NM_017852.5
• UniProt Accession #: Q9NX02
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: NLR family pyrin domain containing 2
• NCBI Official Symbol: NLRP2
• NCBI Official Synonym Symbols: NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 2
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 2
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP2
• UniProt Synonym Gene Names: NALP2; NBS1; PAN1; PYPAF2
• UniProt Entry Name: NALP2_HUMAN

NCBI Description

This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Uniprot Description

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm

Molecular Function: protein binding; Pyrin domain binding; ATP binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion