Human myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) ELISA Kit | KMT2E elisa kit
Human Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
MLL5: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43; Transcription, coactivator/corepressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; intercellular bridge; intracellular membrane-bound organelle; cytoplasm; plasma membrane; nuclear speck
Molecular Function: protein binding; enzyme binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity
Biological Process: retinoic acid receptor signaling pathway; establishment and/or maintenance of chromatin architecture; neutrophil activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone H3-K4 methylation; positive regulation of granulocyte differentiation; neutrophil mediated immunity; DNA methylation; erythrocyte differentiation; cell cycle arrest
Research Articles on KMT2E
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Product Notes
The Human KMT2E kmt2e (Catalog #AAA2602819) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2602819 ELISA Kit recognizes Human KMT2E. It is sometimes possible for the material contained within the vial of "myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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