Human mGluR6 ELISA Kit | mGluR6 elisa kit
mGluR6 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
Uniprot Description
mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: dendrite; endoplasmic reticulum membrane; Golgi membrane; integral component of plasma membrane; plasma membrane; presynaptic membrane
Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; G-protein coupled receptor activity; glutamate receptor activity; protein binding; protein homodimerization activity
Biological Process: detection of light stimulus involved in visual perception; detection of visible light; G-protein coupled glutamate receptor signaling pathway; locomotory behavior; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; regulation of synaptic transmission, glutamatergic; retina development in camera-type eye; synaptic transmission
Disease: Night Blindness, Congenital Stationary, Type 1b
Research Articles on mGluR6
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Product Notes
The Human mGluR6 grm6 (Catalog #AAA9500383) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500383 ELISA Kit recognizes Human mGluR6. It is sometimes possible for the material contained within the vial of "mGluR6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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