Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Membrane protein MLC1 (MLC1) Standard Curve.)
Human Membrane Protein MLC1 (MLC1) ELISA Kit | MLC1 elisa kit
Human Membrane Protein MLC1 (MLC1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Membrane protein MLC1 (MLC1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Membrane protein MLC1 (MLC1) Standard Curve.)
Background: The function of MLC1 product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in MLC1 have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI and Uniprot Product Information
NCBI Description
The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
MLC1: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Defects in MLC1 are a cause of leukoencephalopathy megalencephalic with subcortical cysts type 1 (MLC1). MLC1 is a syndrome of cerebral leukoencephalopathy and megalencephaly characterized by ataxia, spasticity, seizures, delay in motor development and mild mental retardation. The brain appears swollen on magnetic resonance imaging, with diffuse white- matter abnormalities and the invariable presence of subcortical cysts in frontal and temporal lobes.
Protein type: Cell surface; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: clathrin-coated vesicle; lysosome; basolateral plasma membrane; endoplasmic reticulum; early endosome; integral to membrane; intercellular junction; caveola; lipid raft; recycling endosome; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; cytoplasmic vesicle; endosome
Molecular Function: protein binding; transporter activity; protein complex binding; protein transporter activity
Biological Process: vesicle-mediated transport; protein transport; transport; positive regulation of intracellular transport; ion transport; protein oligomerization; regulation of response to osmotic stress
Disease: Megalencephalic Leukoencephalopathy With Subcortical Cysts 1
Research Articles on MLC1
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Product Notes
The Human MLC1 mlc1 (Catalog #AAA9715266) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715266 ELISA Kit recognizes Human MLC1. It is sometimes possible for the material contained within the vial of "Membrane Protein MLC1 (MLC1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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