Human membrane-associated ring finger (C3HC4) 4 ELISA Kit | MARCH4 elisa kit
Human E3 ubiquitin-protein ligase MARCH4, MARCH4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Uniprot Description
MARCH4: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein type: Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: Golgi membrane; Golgi stack; integral to membrane; trans-Golgi network
Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: protein ubiquitination
Research Articles on MARCH4
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Product Notes
The Human MARCH4 march4 (Catalog #AAA9322465) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322465 ELISA Kit recognizes Human MARCH4. It is sometimes possible for the material contained within the vial of "membrane-associated ring finger (C3HC4) 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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