Human Matrix Gla Protein (MGP) ELISA Kit | MGP elisa kit
Human Matrix Gla Protein (MGP) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
Uniprot Description
MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: extracellular matrix structural constituent; protein binding; structural constituent of bone
Biological Process: cartilage condensation
Disease: Keutel Syndrome
Research Articles on MGP
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Product Notes
The Human MGP mgp (Catalog #AAA2087849) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087849 ELISA Kit recognizes Human MGP. It is sometimes possible for the material contained within the vial of "Matrix Gla Protein (MGP), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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