Human lymphocyte factor (LymF) ELISA Kit | LymF elisa kit

Human lymphocyte factor (LymF) ELISA Kit

Cat. Num. AAA260182

• Gene Names: IRF4; MUM1; LSIRF; NF-EM5
• Reactivity: Human
• Synonyms: lymphocyte factor (LymF); Human lymphocyte factor (LymF) ELISA Kit; LymF elisa kit

• Reactivity: Human
• Sequence Length: 450

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 1272477
• NCBI GeneID: 3662
• Molecular Weight: 51,644 Da
• NCBI Official Full Name: lymphocyte specific interferon regulatory factor/interferon regulatory factor 4
• NCBI Official Synonym Full Names: interferon regulatory factor 4
• NCBI Official Symbol: IRF4
• NCBI Official Synonym Symbols: MUM1; LSIRF; NF-EM5
• NCBI Protein Information: interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor
• UniProt Protein Name: Interferon regulatory factor 4
• UniProt Gene Name: IRF4
• UniProt Synonym Gene Names: MUM1; IRF-4; LSIRF
• UniProt Entry Name: IRF4_HUMAN

NCBI Description

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 6p25-p23

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor activity; transcription factor binding

Biological Process: transcription, DNA-dependent; T cell activation; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding

Disease: Skin/hair/eye Pigmentation, Variation In, 8