Human LDLR Chaperone MESD (MESDC2) ELISA Kit | MESDC2 elisa kit
Human LDLR Chaperone MESD (MESDC2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Background: MESDC2 (Mesoderm Development Candidate 2) is a Protein Coding gene. Among its related pathways are Wnt/ Hedgehog/ Notch. GO annotations related to this gene include low-density lipoprotein particle receptor binding. Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
NCBI and Uniprot Product Information
Uniprot Description
MESDC2: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q13
Cellular Component: endoplasmic reticulum; plasma membrane
Molecular Function: low-density lipoprotein receptor binding
Biological Process: Wnt receptor signaling pathway; protein folding; mesoderm development
Research Articles on MESDC2
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Product Notes
The Human MESDC2 mesdc2 (Catalog #AAA9715312) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715312 ELISA Kit recognizes Human MESDC2. It is sometimes possible for the material contained within the vial of "LDLR Chaperone MESD (MESDC2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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