Human Laminin beta3 ELISA Kit | LAMB3 elisa kit

Human Laminin beta3 ELISA Kit

Cat. Num. AAA3803501

• Gene Names: LAMB3; AI1A; LAM5; LAMNB1; BM600-125KDA
• Reactivity: Human
• Synonyms: Laminin beta3; Human Laminin beta3 ELISA Kit; LAMB3 elisa kit

• Reactivity: Human
• Sequence Length: 1172

• Sensitivity: 1 pg/mL
• Intra-assay Precision: Intra-assay CV is less than 15%.
• Inter-assay Precision: Inter-assay CV is less than 15%.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for LAMB3 elisa kit

Intended Uses: This LAMININ beta3 ELISA kit is intended Laboratory for Research use only. The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration of LAMININ beta3 in the sample, this LAMININ beta3 ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus LAMININ beta3 concentration. The concentration of LAMININ beta3 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 189083719
• NCBI GeneID: 3914
• NCBI GenBank Nucleotide #: NP_001121113.1
• UniProt Accession #: Q13751
• NCBI Official Full Name: laminin subunit beta-3
• NCBI Official Synonym Full Names: laminin subunit beta 3
• NCBI Official Symbol: LAMB3
• NCBI Official Synonym Symbols: AI1A; LAM5; LAMNB1; BM600-125KDA
• NCBI Protein Information: laminin subunit beta-3
• UniProt Protein Name: Laminin subunit beta-3
• Protein Family: Laminin
• UniProt Gene Name: LAMB3
• UniProt Synonym Gene Names: LAMNB1
• UniProt Entry Name: LAMB3_HUMAN

NCBI Description

The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LAMB3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: laminin-5 complex; extracellular region

Molecular Function: protein binding; protein complex binding; structural molecule activity

Biological Process: extracellular matrix disassembly; epidermis development; hemidesmosome assembly; extracellular matrix organization and biogenesis; brown fat cell differentiation; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type; Amelogenesis Imperfecta, Type Ia