Human KAT6A/Histone Acetyltransferase KAT6A ELISA Kit | KAT6A elisa kit
Human KAT6A/Histone Acetyltransferase KAT6A ELISA Kit
Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Description
MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family.
Protein type: Acetyltransferase; Oncoprotein; Nucleolus; EC 2.3.1.48
Chromosomal Location of Human Ortholog: 8p11
Cellular Component: nucleoplasm; Golgi apparatus; PML body; nucleolus; nucleosome; nucleus
Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; zinc ion binding; transcription coactivator activity; acetyltransferase activity; chromatin binding; transcription factor binding
Biological Process: heart morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; embryonic hemopoiesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; nucleosome assembly; protein amino acid acetylation; myeloid cell differentiation; histone acetylation; negative regulation of transcription, DNA-dependent; DNA packaging
Disease: Mental Retardation, Autosomal Dominant 32
Research Articles on KAT6A
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Product Notes
The Human KAT6A kat6a (Catalog #AAA2890853) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2890853 ELISA Kit recognizes Human KAT6A. It is sometimes possible for the material contained within the vial of "KAT6A/Histone Acetyltransferase KAT6A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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