Human Intermediate Conductance Calcium-Activated Potassium Channel Protein 4, KCNN4 ELISA Kit | KCNN4 elisa kit
Human Intermediate Conductance Calcium-Activated Potassium Channel Protein 4, KCNN4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: voltage-gated potassium channel complex; cell soma; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft
Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein binding; Intermediate conductance calcium-activated potassium channel activity; small conductance calcium-activated potassium channel activity; protein phosphatase binding
Biological Process: phospholipid translocation; synaptic transmission; positive regulation of T cell receptor signaling pathway; positive regulation of protein secretion; immune system process; calcium ion transport; defense response; cell volume homeostasis; saliva secretion; stabilization of membrane potential; potassium ion transport
Research Articles on KCNN4
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Product Notes
The Human KCNN4 kcnn4 (Catalog #AAA1603916) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1603916 ELISA Kit recognizes Human KCNN4. It is sometimes possible for the material contained within the vial of "Intermediate Conductance Calcium-Activated Potassium Channel Protein 4, KCNN4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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