Human Interleukin-18 receptor accessory protein, IL18RAP ELISA Kit | IL18RAP elisa kit
Human Interleukin-18 receptor accessory protein, IL18RAP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Uniprot Description
IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: integral to membrane
Molecular Function: receptor activity
Biological Process: cell surface receptor linked signal transduction; immune response; inflammatory response
Research Articles on IL18RAP
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Product Notes
The Human IL18RAP il18rap (Catalog #AAA1606420) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1606420 ELISA Kit recognizes Human IL18RAP. It is sometimes possible for the material contained within the vial of "Interleukin-18 receptor accessory protein, IL18RAP, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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