Human Interferon Regulatory Factor 3 (IRF3) ELISA Kit | IRF3 elisa kit

Human Interferon Regulatory Factor 3 (IRF3) ELISA Kit

Cat. Num. AAA3802539

• Gene Names: Irf3; IRF-3; C920001K05Rik
• Reactivity: Human
• Synonyms: Interferon Regulatory Factor 3 (IRF3); Human Interferon Regulatory Factor 3 (IRF3) ELISA Kit; IRF3 elisa kit

• Reactivity: Human
• Sequence Length: 419

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 62.5 pg/ml-1000 pg/ml
• Sensitivity: 1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for IRF3 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofIRF3in the sample, This IRF3ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusIRF3concentration. The concentration ofIRF3in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 8393627
• NCBI GeneID: 54131
• NCBI Accession #: NP_058545.1
• NCBI GenBank Nucleotide #: NP_058545.1
• UniProt Accession #: P70671
• NCBI Official Full Name: interferon regulatory factor 3
• NCBI Official Synonym Full Names: interferon regulatory factor 3
• NCBI Official Symbol: Irf3
• NCBI Official Synonym Symbols: IRF-3; C920001K05Rik
• NCBI Protein Information: interferon regulatory factor 3
• UniProt Protein Name: Interferon regulatory factor 3
• Protein Family: Interferon regulatory factor
• UniProt Gene Name: Irf3
• UniProt Synonym Gene Names: IRF-3

Uniprot Description

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.