Human Interferon-induced transmembrane protein 3, IFITM3 ELISA Kit | IFITM3 elisa kit

Human Interferon-induced transmembrane protein 3, IFITM3 ELISA Kit

Cat. Num. AAA2602698

• Gene Names: IFITM3; 1-8U; IP15; DSPA2b
• Reactivity: Human
• Synonyms: Interferon-induced transmembrane protein 3; IFITM3; Human Interferon-induced transmembrane protein 3; IFITM3 ELISA Kit; IFITM3 elisa kit

• Reactivity: Human
• Specificity: No cross-reaction with other factors.

• Samples: Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant IFITM3 concentration.
• Assay Type: Sandwich
• Detection Range: 20 ng/ml-0.312 ng/ml
• Sensitivity: 0.06 ng/ml.
• Intra-assay Precision: <= 8%
• Inter-assay Precision: <= 12%
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve

Related Product Information for IFITM3 elisa kit

Principle of the Assay||This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human IFITM3 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

NCBI and Uniprot Product Information

• NCBI GI #: 148612842
• NCBI GeneID: 10410
• NCBI Accession #: NP_066362.2
• NCBI GenBank Nucleotide #: NM_021034.2
• UniProt Accession #: Q01628; Q53Y76; Q96HK8; Q96J15
• Molecular Weight: 14,632 Da
• NCBI Official Full Name: interferon-induced transmembrane protein 3
• NCBI Official Synonym Full Names: interferon induced transmembrane protein 3
• NCBI Official Symbol: IFITM3
• NCBI Official Synonym Symbols: 1-8U; IP15; DSPA2b
• NCBI Protein Information: interferon-induced transmembrane protein 3; dispanin subfamily A member 2b; interferon-inducible protein 1-8U
• UniProt Protein Name: Interferon-induced transmembrane protein 3
• Protein Family: Interferon-induced transmembrane protein
• UniProt Gene Name: IFITM3
• UniProt Synonym Gene Names: DSPA2b
• UniProt Entry Name: IFM3_HUMAN

NCBI Description

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

Uniprot Description

IFITM3: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of viral transcription; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; response to virus; immune response; defense response to virus

Disease: Influenza, Severe, Susceptibility To