Human ICE protease-activating factor, IRAP ELISA Kit | IRAP elisa kit
Human ICE protease-activating factor, IRAP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008]
Uniprot Description
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle microtubule; cytoplasm; intracellular; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity; magnesium ion binding; cysteine protease inhibitor activity; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; regulation of neuron apoptosis; defense response to bacterium; protein ubiquitination; regulation of signal transduction; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; negative regulation of apoptosis; activation of NF-kappaB transcription factor
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Research Articles on IRAP
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Product Notes
The Human IRAP nlrc4 (Catalog #AAA9303561) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9303561 ELISA Kit recognizes Human IRAP. It is sometimes possible for the material contained within the vial of "ICE protease-activating factor, IRAP, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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