Human HSP27 ELISA Kit | HSP27 elisa kit
Phospho-HSP27 (Ser78) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Uniprot Description
HSP27: a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
Protein type: Chaperone; Heat shock protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: axon cytoplasm; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular matrix; extracellular space; focal adhesion; nucleus; plasma membrane; proteasome complex; spindle; Z disc
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; ubiquitin binding
Biological Process: cell motility; negative regulation of apoptosis; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor biosynthetic process; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of mRNA stability; regulation of protein amino acid phosphorylation; regulation of translational initiation; response to unfolded protein; response to virus; retinal homeostasis; vascular endothelial growth factor receptor signaling pathway
Disease: Charcot-marie-tooth Disease, Axonal, Type 2f; Neuronopathy, Distal Hereditary Motor, Type Iib
Research Articles on HSP27
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Product Notes
The Human HSP27 hspb1 (Catalog #AAA9501477) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501477 ELISA Kit recognizes Human HSP27. It is sometimes possible for the material contained within the vial of "HSP27, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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