Typical Testing Data/Standard Curve (for reference only)
Human Glucocorticoid Receptor Beta (GRb) ELISA Kit | GRb elisa kit
Human Glucocorticoid Receptor Beta (GRb) ELISA Kit
No significant cross-reactivity or interference between Glucocorticoid Receptor Beta (GRb) and analogues was observed.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Uniprot Description
GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.
Protein type: DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cytoplasm; cytosol; microtubule organizing center; mitochondrial matrix; nuclear speck; nucleoplasm; nucleus; protein complex; spindle
Molecular Function: DNA binding transcription factor activity; glucocorticoid receptor activity; glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity; Hsp90 protein binding; protein binding; protein kinase binding; RNA binding; steroid binding; steroid hormone binding; SUMO binding; zinc ion binding
Biological Process: apoptosis; cell cycle; cell division; cellular response to dexamethasone stimulus; cellular response to glucocorticoid stimulus; cellular response to steroid hormone stimulus; cellular response to transforming growth factor beta stimulus; chromosome segregation; covalent chromatin modification; glucocorticoid mediated signaling pathway; glucocorticoid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Glucocorticoid Resistance, Generalized
Research Articles on GRb
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Product Notes
The Human GRb nr3c1 (Catalog #AAA2702438) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2702438 ELISA Kit recognizes Human GRb. It is sometimes possible for the material contained within the vial of "Glucocorticoid Receptor Beta (GRb), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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