Human Fc Fragment Of IgA Receptor (FcaR) ELISA Kit | FcaR elisa kit

Human Fc Fragment Of IgA Receptor (FcaR) ELISA Kit

Cat. Num. AAA2703270

• Gene Names: FCAR; CD89; FcalphaRI; CTB-61M7.2
• Reactivity: Human
• Synonyms: Fc Fragment Of IgA Receptor (FcaR); Human Fc Fragment Of IgA Receptor (FcaR) ELISA Kit; CD89; FcaRI; Receptor I For The Fc Region Of Immunoglobulin A; IgA Fc receptor; Immunoglobulin alpha Fc receptor; FcaR elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Fc Fragment Of IgA Receptor (FcaR).; No significant cross-reactivity or interference between Fc Fragment Of IgA Receptor (FcaR) and analogues was observed.
• Sequence Length: 253

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma, Tissue Homogenates and Other Biological Fluids
• Detection Range: 0.78-50ng/mL
• Sensitivity: < 0.37ng/mL
• Application: Enzyme-linked immunosorbent assay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Fc Fragment Of IgA Receptor (FcaR) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Fc Fragment Of IgA Receptor (FcaR) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for FcaR elisa kit

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Fc Fragment Of IgA Receptor (FcaR). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Fc Fragment Of IgA Receptor (FcaR). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Fc Fragment Of IgA Receptor (FcaR), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Fc Fragment Of IgA Receptor (FcaR) in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 119592713
• NCBI GeneID: 2204
• UniProt Accession #: P24071; Q13603; Q13604; Q15727; Q15728; Q1AJL7; Q1AJL8; Q1AJL9; Q53X38; Q53X39; Q92587; Q92588
• Molecular Weight: 28,343 Da
• NCBI Official Full Name: Fc fragment of IgA, receptor for, isoform CRA_f
• NCBI Official Synonym Full Names: Fc fragment of IgA receptor
• NCBI Official Symbol: FCAR
• NCBI Official Synonym Symbols: CD89; FcalphaRI; CTB-61M7.2
• NCBI Protein Information: immunoglobulin alpha Fc receptor
• UniProt Protein Name: Immunoglobulin alpha Fc receptor
• Protein Family: Immunoglobulin alpha Fc receptor
• UniProt Gene Name: FCAR
• UniProt Synonym Gene Names: CD89; IgA Fc receptor

NCBI Description

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.