Human F box/LRR repeat protein 7 (FBXL7) ELISA Kit | FBXL7 elisa kit
Human F box/LRR repeat protein 7 (FBXL7) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Uniprot Description
FBXL7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. Belongs to the FBXL7 family.
Chromosomal Location of Human Ortholog: 5p15.1
Cellular Component: centrosome; cytoplasm; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function: ubiquitin-protein ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; mitosis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; protein ubiquitination; G2/M transition of mitotic cell cycle
Research Articles on FBXL7
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Product Notes
The Human FBXL7 fbxl7 (Catalog #AAA7247415) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7247415 ELISA Kit recognizes Human FBXL7. It is sometimes possible for the material contained within the vial of "F box/LRR repeat protein 7 (FBXL7), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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