Human EPHB2 ELISA Kit | EPHB2 elisa kit
EPHB2 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Uniprot Description
EphB2: a receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members. Activated EphB2 recruits RasGAP, down-regulating the Ras-Erk signaling axis and neurite retraction. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB2 interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Point mutations seen in prostate cancer. Overexpressed and required for migration of glioblastoma. Overexpressed and correlated with poor survival in breast cancer. Overexpression and loss of heterozygosity seen in colorectal cancers. Target for immunoconjugate drug therapy .Three splice-variant isoforms have been described.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: axon; cell soma; cytosol; dendrite; extracellular region; integral component of plasma membrane; nucleus; plasma membrane; postsynapse
Molecular Function: amyloid-beta binding; ATP binding; axon guidance receptor activity; identical protein binding; protein binding; protein tyrosine kinase activity; receptor binding; transmembrane-ephrin receptor activity
Biological Process: angiogenesis; axon guidance; axonal fasciculation; camera-type eye morphogenesis; central nervous system projection neuron axonogenesis; commissural neuron axon guidance; corpus callosum development; ephrin receptor signaling pathway; inactivation of MAPKK activity; inner ear morphogenesis; learning; learning and/or memory; negative regulation of axonogenesis; negative regulation of ERK1 and ERK2 cascade; negative regulation of NMDA glutamate receptor activity; negative regulation of protein phosphorylation; negative regulation of Ras protein signal transduction; nervous system development; neuron projection retraction; optic nerve morphogenesis; palate development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of gene expression; positive regulation of long-term neuronal synaptic plasticity; positive regulation of long-term synaptic potentiation; positive regulation of NMDA glutamate receptor activity; positive regulation of synaptic plasticity; positive regulation of synaptogenesis; regulation of body fluid levels; regulation of neuronal synaptic plasticity; retinal ganglion cell axon guidance; urogenital system development
Disease: Prostate Cancer/brain Cancer Susceptibility
Research Articles on EPHB2
Similar Products
Product Notes
The Human EPHB2 ephb2 (Catalog #AAA9500205) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500205 ELISA Kit recognizes Human EPHB2. It is sometimes possible for the material contained within the vial of "EPHB2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
