Human Dystrophin Associated Glycoprotein 1 (DAG1) ELISA Kit | DAG1 elisa kit

Human Dystrophin Associated Glycoprotein 1 (DAG1) ELISA Kit

Cat. Num. AAA3800727

• Gene Names: Dag1; DG; Dp71; Dp427; D9Wsu13e
• Reactivity: Human
• Synonyms: Dystrophin Associated Glycoprotein 1 (DAG1); Human Dystrophin Associated Glycoprotein 1 (DAG1) ELISA Kit; DAG1 elisa kit

• Reactivity: Human
• Sequence Length: 893

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 1ng/ml-16ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for DAG1 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofDAG1in the sample, This DAG1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusDAG1concentration. The concentration ofDAG1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 451898104
• NCBI GeneID: 13138
• NCBI Accession #: NP_001263410.1
• NCBI GenBank Nucleotide #: NP_001263410.1
• UniProt Accession #: Q62165
• NCBI Official Full Name: dystroglycan preproprotein
• NCBI Official Synonym Full Names: dystroglycan 1
• NCBI Official Symbol: Dag1
• NCBI Official Synonym Symbols: DG; Dp71; Dp427; D9Wsu13e
• NCBI Protein Information: dystroglycan
• UniProt Protein Name: Dystroglycan
• Protein Family: Dystroglycan
• UniProt Gene Name: Dag1
• UniProt Synonym Gene Names: Dag-1; Alpha-DG; Beta-DG

NCBI Description

This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]

Uniprot Description

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also receptor for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity ().