Human DNA Methyltransferase 3B (DNMT3B) ELISA Kit | DNMT3B elisa kit

Human DNA Methyltransferase 3B (DNMT3B) ELISA Kit

Cat. Num. AAA3802641

• Gene Names: Dnmt3b; MmuIIIB
• Reactivity: Human
• Synonyms: DNA Methyltransferase 3B (DNMT3B); Human DNA Methyltransferase 3B (DNMT3B) ELISA Kit; DNMT3B elisa kit

• Reactivity: Human
• Sequence Length: 839

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 1.25ng/ml-20ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for DNMT3B elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofDNMT3B ANTIBODYin the sample, This DNMT3B ANTIBODYELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusDNMT3B ANTIBODYconcentration. The concentration ofDNMT3B ANTIBODYin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 172088101
• NCBI GeneID: 13436
• NCBI Accession #: NP_001003960.2
• NCBI GenBank Nucleotide #: NP_001003960.2
• UniProt Accession #: O88509
• NCBI Official Full Name: DNA (cytosine-5)-methyltransferase 3B isoform 2
• NCBI Official Synonym Full Names: DNA methyltransferase 3B
• NCBI Official Symbol: Dnmt3b
• NCBI Official Synonym Symbols: MmuIIIB
• NCBI Protein Information: DNA (cytosine-5)-methyltransferase 3B
• UniProt Protein Name: DNA (cytosine-5)-methyltransferase 3B
• Protein Family: DNA
• UniProt Gene Name: Dnmt3b
• UniProt Synonym Gene Names: Dnmt3b; DNA MTase MmuIIIB; M.MmuIIIB

NCBI Description

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Uniprot Description

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 ().