Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Disks large homolog 5 (DLG5) Standard Curve.)
Human Disks Large Homolog 5 (DLG5) ELISA Kit | DLG5 elisa kit
Human Disks Large Homolog 5 (DLG5) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Disks large homolog 5 (DLG5) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Disks large homolog 5 (DLG5) Standard Curve.)
Background: DLG5 encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
DLG5: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton. Belongs to the MAGUK family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q23
Cellular Component: cell-cell adherens junction; cytoplasm; plasma membrane
Molecular Function: protein binding; receptor signaling complex scaffold activity; cytoskeletal protein binding; beta-catenin binding
Biological Process: establishment and/or maintenance of epithelial cell polarity; regulation of apoptosis; polarized epithelial cell differentiation; negative regulation of cell proliferation; apical protein localization; cell-cell adhesion; midbrain development; zonula adherens assembly; protein complex assembly; signal transduction
Disease: Inflammatory Bowel Disease 1
Research Articles on DLG5
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Product Notes
The Human DLG5 dlg5 (Catalog #AAA9715689) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715689 ELISA Kit recognizes Human DLG5. It is sometimes possible for the material contained within the vial of "Disks Large Homolog 5 (DLG5), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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