Human Dickkopf Related Protein 2 (DKK2) ELISA Kit | DKK2 elisa kit

Human Dickkopf Related Protein 2 (DKK2) ELISA Kit

Cat. Num. AAA455136

• Gene Names: DKK2; DKK-2
• Reactivity: Human
• Synonyms: Dickkopf Related Protein 2 (DKK2); Human Dickkopf Related Protein 2 (DKK2) ELISA Kit; Dickkopf Homolog 2(Xenopus Laevis); DKK2 elisa kit

• Reactivity: Human
• Sequence Length: 259

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 78.125-5000pg/mL
• Sensitivity: 34pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 7657023
• NCBI GeneID: 27123
• NCBI Accession #: NP_055236.1
• NCBI GenBank Nucleotide #: NM_014421.2
• UniProt Accession #: Q9UBU2; Q9UIU3; A0AVE9; B2R6S7
• Molecular Weight: 28,447 Da
• NCBI Official Full Name: dickkopf-related protein 2
• NCBI Official Synonym Full Names: dickkopf WNT signaling pathway inhibitor 2
• NCBI Official Symbol: DKK2
• NCBI Official Synonym Symbols: DKK-2
• NCBI Protein Information: dickkopf-related protein 2
• UniProt Protein Name: Dickkopf-related protein 2
• Protein Family: Dickkopf-related protein
• UniProt Gene Name: DKK2
• UniProt Synonym Gene Names: Dickkopf-2; Dkk-2; hDkk-2

NCBI Description

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

Uniprot Description

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease ().