Human Derlin 1 (DERL1) ELISA Kit | DERL1 elisa kit

Human Derlin 1 (DERL1) ELISA Kit

Cat. Num. AAA9311262

• Reactivity: Human
• Synonyms: Derlin 1 (DERL1); Human Derlin 1 (DERL1) ELISA Kit; DERL1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 45430007
• NCBI GeneID: 404121
• NCBI Accession #: NP_991358.1
• NCBI GenBank Nucleotide #: NM_205789.1
• UniProt Accession #: Q71SS4; Q1RMX8
• Molecular Weight: 28,865 Da
• NCBI Official Full Name: derlin-1
• NCBI Official Symbol: DERL1
• NCBI Protein Information: derlin-1; der1-like protein 1; Der1-like domain family, member 1; degradation in endoplasmic reticulum protein 1
• UniProt Protein Name: Derlin-1
• Protein Family: Probable derlin
• UniProt Gene Name: DERL1
• UniProt Synonym Gene Names: DER1
• UniProt Entry Name: DERL1_BOVIN

Uniprot Description

Function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate

By similarity.

Subunit structure: Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, SELS/VIMP, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-SELS protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with NGLY1 and YOD1. Does not bind to EDEM1

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity.

Induction: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR)

By similarity.

Sequence similarities: Belongs to the derlin family.